STIMULUS CONTROLLABILITY CAN MODULATE THE INDUCTION OF HFS-INDUCED CENTRAL SENSITIZATION
(2019) 11th Congress of the European Pain Federation Efic — Location: Valencia, Spain (4.September.2019)
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- Authors
van den Broeke, Emanuel 
- Abstract
- Background and aims. Central sensitization (CS) is a use-dependent synaptic plasticity often associated with chronic pain. Studies have shown that the intensity of pain perception and the magnitude of pain-evoked brain responses can be modulated by emotional and cognitive factors. Whether these factors may also affect the induction of CS and resulting hyperalgesia remains largely unknown. Behavioral control over pain has been shown to reduce pain perception. Here, we tested whether pain controllability modulates the experimental induction of CS by high frequency electrical stimulation (HFS) of cutaneous nociceptors, as evaluated by the measurement of secondary hyperalgesia. Methods. HFS was applied to the left or rig ht forearm of healthy participants in two sessions separated by >1 week (five 1-s trains of 100-Hz pulses, 20x detection threshold, inter-train interval: 15-20 s). In the 'control' session, participants self-administered HFS by pushing a button triggering each of the five trains. In the 'no control' session, HFS was delivered at the times corresponding to their delivery in the 'no control' session of another participant. The order of sessions was balanced across participants. The extent of HFS-induced CS and secondary hyperalgesia was assessed by measuring pinprick sensitivity at both forearms, before and 20 minutes after HFS. Results. The increa se in pinprick sensitivity at the HFS-treated forearm was significantly greater in the 'control' vs. the 'no control' sessions. Conclusions. Although previous studies sh owed that self-administration of nociceptive stimuli reduces pain perception, our results indicate behavioral control over nociceptive stimulation paradoxically increases secondary hyperalgesia and probably CS.
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Citations
Nicolardi, V., van den Broeke, E., Filbrich, L., Legrain, V., & Mouraux, A. (2019). STIMULUS CONTROLLABILITY CAN MODULATE THE INDUCTION OF HFS-INDUCED CENTRAL SENSITIZATION. 11th Congress of the European Pain Federation Efic, Valencia, Spain. https://hdl.handle.net/2078.5/126134