Interactions between Avibactam and Ceftazidime-Hydrolyzing Class D β-Lactamases.

Frère, Jean-Marie;Bogaerts, Pierre;Huang, Te-Din;Stefanic, Patrick;Brans, Alain;et.al.
(2020) Biomolecules — Vol. 10, n° 3, p. 483 [1-14] (2020)

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Abstract
Class D β-lactamases exhibit very heterogeneous hydrolysis activity spectra against the various types of clinically useful β-lactams. Similarly, and according to the available data, their sensitivities to inactivation by avibactam can vary by a factor of more than 100. In this paper, we performed a detailed kinetic study of the interactions between two ceftazidime-hydrolyzing OXA enzymes and showed that they were significantly more susceptible to avibactam than several other class D enzymes that do not hydrolyze ceftazidime. From a clinical point of view, this result is rather interesting if one considers that avibactam is often administered in combination with ceftazidime.
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Frère, J.-M., Bogaerts, P., Huang, T.-D., Stefanic, P., Moray, J., Bouillenne, F., & Brans, A. (2020). Interactions between Avibactam and Ceftazidime-Hydrolyzing Class D β-Lactamases. Biomolecules, 10(3), 483 [1-14]. https://doi.org/10.3390/biom10030483 (Original work published 2020)