Making friends out of foes: novel therapeutic approaches for haemophilia.
(2021) Blood transfusion = Trasfusione del sangue — Vol. 19, n° 2, p. 179-180 (2021)
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- Dear Sir, The currently most promising treatments of haemophilia are gene therapy based on inactivated viral vectors and immunotherapy using a bispecific antibody mimicking the catalytic action of factor VIII (FVIII). Considering the past viral contamination of the haemophilia community and the persistent unavoidable and challenging development of neutralizing antibodies mainly against exogenous FVIII, it was not expected that viral vectors and antibodies would serve to develop and validate treating or curing approaches for patients with haemophilia. [ … ]
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Mactier, C., & Hermans, C. (2021). Making friends out of foes: novel therapeutic approaches for haemophilia. Blood transfusion = Trasfusione del sangue, 19(2), 179-180. https://doi.org/10.2450/2020.2020.0403-20 (Original work published 2021)