Muscle histidine-containing dipeptides are elevated by glucose intolerance in both rodents and men

Stegen, Sanne;Everaert, Inge;Deldicque, Louise;Vallova, Silvia;Derave, Wim;et.al.
(2015) PLoS One — Vol. 10, n° 3, p. e0121062 (2015)

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Authors
  • Stegen, SanneGhent University
    Author
  • Everaert, IngeGhent University
    Author
  • Author
  • Vallova, SilviaComenius University, Bratislava
    Author
  • Derave, WimGhent University
    Author
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Abstract
Muscle carnosine and its methylated form anserine are histidine-containing dipeptides. Both dipeptides have the ability to quench reactive carbonyl species and previous studies have shown that endogenous tissue levels are decreased in chronic diseases, such as diabetes.
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Citations

Stegen, S., Everaert, I., Deldicque, L., Vallova, S., de Courten, B., Ukropcova, B., Ukropec, J., & Derave, W. (2015). Muscle histidine-containing dipeptides are elevated by glucose intolerance in both rodents and men. PLoS One, 10(3), e0121062. https://doi.org/10.1371/journal.pone.0121062 (Original work published 2015)