Temocillin and piperacillin/tazobactam resistance by disc diffusion as antimicrobial surrogate markers for the detection of carbapenemase-producing Enterobacteriaceae in geographical areas with a high prevalence of OXA-48 producers.

Huang, Te-Din;Poirel, Laurent;Bogaerts, Pierre;Berhin, Catherine;Glupczynski, Gerald;et.al.
(2013) Journal of Antimicrobial Chemotherapy — (2013)

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Abstract
In geographical areas with a high prevalence of OXA-48 producers, recommended meropenem susceptibility or screening breakpoints failed to detect CPE in a large proportion of isolates. The combination of modified zone diameter cut-offs for piperacillin/tazobactam (≥16 mm) and temocillin (≥12 mm) can be used to rule out the presence of carbapenemase and avoid unnecessary additional testing for confirmation of CPE.
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Huang, T.-D., Poirel, L., Bogaerts, P., Berhin, C., Nordmann, P., & Glupczynski, G. (2013). Temocillin and piperacillin/tazobactam resistance by disc diffusion as antimicrobial surrogate markers for the detection of carbapenemase-producing Enterobacteriaceae in geographical areas with a high prevalence of OXA-48 producers. Journal of Antimicrobial Chemotherapy. Accepted/in-press. https://doi.org/10.1093/jac/dkt367 (Original work published 2013)