To identify an accurate and reproducible method to define myocardial infarct (MI) size, we conducted a study in a closed-chest canine model of acute myocardial infarction, in which MI size was measured using different thresholding techniques and by imaging at different delay times after contrast administration.
Amado, L. C., Gerber, B., Gupta, S. N., Rettmann, D. W., Szarf, G., Schock, R., Nasir, K., Kraitchman, D. L., & Lima, J. A. C. (2004). Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model. Journal of the american college of cardiology : JACC, 44(12), 2383-2389. https://doi.org/10.1016/j.jacc.2004.09.020 (Original work published 2004)