Dermatomyositis with anti-TIF1-γ antibodies

(en) We report the case of a 61-year-old Turkish male patient who presented to our dermatology outpatient clinic with a 1-year history of swelling and pruritic erythema rash of the face and trunk. He reported associated myalgia and arthralgia of the knees and wrists. Two months before presentation, he developed muscle weakness of upper limbs and dyspnoea. On review, he was noted to have unintentional weight loss (5 kg over 2 months) and increasing fatigue. His medical and family histories were unremarkable. His medications included omeprazole daily and vitamin B12 injections. Prior to presentation to our clinic, his general practitioner treated the patient with antihistamines, topical steroids (Elocom) and a short course of oral corticosteroid therapy which only provided temporary relief. Laboratory data demonstrated C reactive protein 6 mg/L (normal value (NV) <5 mg/L), haemoglobin 11.9 g/dL (NV 13–18 g/dL), lactate dehydrogenase 467 U/L (NV 135–225 U/L), creatinine phosphokinase 295 U/L (NV 30–190 U/L), Aspartate transaminase (GOT) 75 U/L (NV 8–31 U/L), Glutamate pyruvate transaminase (GPT) 66 U/L (NV 5–31 U/L); white blood count, ionogram, lipid profile, renal function, thyroid function, haemostasis and coagulation were all normal. Hepatitis B and C, and HIV serologies were all negative. Antinuclear antibodies were positive at 1/320. Serum protein immunoelectrophoresis showed a polyclonal raise of IgG up to 21.0 g/L (normal range at 7–15 g/L).

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De Greef, A., Marot, L., Yildiz, H., & Baeck, M. (2018). Dermatomyositis with anti-TIF1-γ antibodies. BMJ Case Reports, bcr-2018. https://doi.org/10.1136/bcr-2018-227574 (Original work published 2018)