Our preclinical data indicate that KDs could be considered as an auxiliary therapy of wild-type, NRAS mutated as well as BRAF mutated melanomas. Further analysis will reveal whether the anti-tumor effects could be associated with unique metabolic changes induced by KDs. The effect of KD on melanoma progression was independent of the immune status of the mice, indicating that the effect of the KDs on tumor proliferation does not entirely depend on an intact immune system as suggested recently.
Affiliations
Paracelsus Medical University
Citations
APA
Chicago
FWB
Daniela D Weber, Sepideh Aminzadeh-Gohari, Luca Catalano, Anna-Sophia Redtenbacher, Julia Tevini, Thomas Felder, Peter Kölblinger, René G Feichtinger, De Miranda Capeloa, T. I., Sonveaux, P., Roland Lang, Barbara Kofler, & et al. (2021). Ketogenic diet reduces melanoma growth independently of the mutation status and metabolic signature. Tumor Metabolism and the Microenvironment, online. https://hdl.handle.net/2078.5/112625