Metabolic control by AMPK in white adipose tissue.
(2023) Trends in Endocrinology and Metabolism — Vol. 34, n° 11, p. 704-717 (2023)
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- Authors
Rider, Mark H. 
- Abstract
- White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when treating type 2 diabetes with pharmacological pan-AMPK activators.
- Affiliations
Citations
Göransson, O., Kopietz, F., & Rider, M. H. (2023). Metabolic control by AMPK in white adipose tissue. Trends in Endocrinology and Metabolism, 34(11), 704-717. https://doi.org/10.1016/j.tem.2023.08.011 (Original work published 2023)