Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome?

Kadhim, Hazim;Kahn, André;Sébire, Guillaume
(2003) Neurology —

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  • Kadhim, HazimUCLouvain
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  • Kahn, André
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  • Sébire, Guillaume
    Author
Abstract
Cytokines modify neuronal function. Dysfunction in vital centers is reported in sudden infant death syndrome (SIDS). The authors detected high neuronal interleukin (IL)-1beta immunoreactivity in the arcuate and dorsal vagal nuclei in SIDS. This IL-1 overexpression might contribute to molecular interactions in brainstem neurovegetative centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.
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Kadhim, H., Kahn, A., & Sébire, G. (2003). Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome? Neurology. https://doi.org/10.1212/01.WNL.0000092014.14997.47