Understanding biological response of pulp cells to dental composites and how to improve their biocompatibility
(2026)
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Understandingbiologicalresponseofpulpcellstodentalcompositesandhowtoimprovetheirbiocompatibility.pdf
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- Abstract
- This thesis examines dental composites as dynamic materials interacting with the dental pulp. It shows that incomplete polymerization leads to the elution of monomers and initiators that can induce oxidative stress and sublethal effects on pulp cells, especially under real clinical conditions (curing depth, light-curing protocols). The work assesses both physico-mechanical performance (degree of conversion, hardness, strength) and biological responses, and explores strategies to improve biocompatibility, notably the incorporation of antioxidants (N-acetylcysteine). The findings are discussed in light of ISO/MDR frameworks, highlighting the gap between standardized tests and clinical reality, and propose pathways to design safer composites without compromising performance.
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Gilli, M. (2026). Understanding biological response of pulp cells to dental composites and how to improve their biocompatibility. https://hdl.handle.net/2078.5/274023