C-terminal FGF23 is a strong predictor of survival in systolic heart failure
(2012) Peptides — Vol. 37, n° 2, p. 258-262 (2012)
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- Fibroblast growth factor 23 (FGF23) is a bone-derived hormone involved in the regulation of phosphate and calcium metabolism. We have evaluated the levels of C-terminal FGF23 (Ct-FGF23) in 73 patients presenting heart failure with reduced ejection fraction (HF-REF) and assess their potential predictive value for long-term survival through a 6 years follow-up. Ct-FGF23 levels were markedly increased in HF-REF. In univariate proportional hazard model, survival was related to glomerular filtration rate (eGFR), intact parathyroid hormone (PTH), B-type natriuretic peptides (BNP) and Ct-FGF23. In a multivariate analysis including age, EF, PTH, BNP, Ct-FGF23, calcium, phosphorus and eGFR levels, Ct-FGF23 is the strongest predictor of long term CV death.
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Gruson, D., Lepoutre, T., Ketelslegers, J.-M., Cumps, J., Ahn, S. A., & Rousseau, M. (2012). C-terminal FGF23 is a strong predictor of survival in systolic heart failure. Peptides, 37(2), 258-262. https://doi.org/10.1016/j.peptides.2012.08.003 (Original work published 2012)