Synthesis, Structure and Reactions of Seco-steroids Containing a Medium-sized Ring .26. Structure Determination of Isoxazolidine Derivatives Obtained From (e)-unsaturated 5,10-seco-steroidal Ketones

Tinant, Bernard;Declercq, Jean-Paul;Van-Meerssche, M.;Mihailovic, ML.;Milovanovic, A.;et.al.
(1988) Societes Chimiques Belges. Bulletin — Vol. 97, n° 7, p. 485-491 (1988)

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  • Tinant, BernardUCLouvain
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  • Declercq, Jean-PaulUCLouvain
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  • Van-Meerssche, M.autre
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  • Mihailovic, ML.
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  • Milovanovic, A.
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Abstract
(E)-Δ*1(10) -unsaturated 5-oxo-5,10-seco-steroids such as 1, react with hydroxylamine and N-methylhydroxylamine to give stereospecifically isoxazolidine derivatives of type 2 and 3, respectively. The molecular structure of isoxazolidine 3a obtained from (E)-3β-acetoxy-5,10-seco-cholest-1 (10)-en-5-one (la) and N-methylhydroxylamine has been determined by X-ray analysis.
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Tinant, B., Declercq, J.-P., Van-Meerssche, M., Mihailovic, ML., Lorenc, L., Rajkovic, M., & Milovanovic, A. (1988). Synthesis, Structure and Reactions of Seco-steroids Containing a Medium-sized Ring .26. Structure Determination of Isoxazolidine Derivatives Obtained From (e)-unsaturated 5,10-seco-steroidal Ketones. Societes Chimiques Belges. Bulletin, 97(7), 485-491. https://doi.org/10.1002/bscb.19880970704 (Original work published 1988)