The present study supports the idea that during endurance exercise, TLR2 and TLR4 mediate a signal linking the elevated plasma NEFA concentration to the activation of p38 MAPK and JNK.
Zbinden Foncea, H. P., Raymackers, J.-M., Deldicque, L., Renard, P., & Francaux, M. (2012). TLR2 and TLR4 Activate p38 MAPK and JNK during Endurance Exercise in Skeletal Muscle. Medicine and Science in Sports and Exercise, 44(8), 1463-1472. https://doi.org/10.1249/MSS.0b013e31824e0d5d (Original work published 2012)