Role of laminin-111 in pancreatic acinar differentiation and of MarvelD3 in pancreas development and disease
(2020)
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- Authors
- Supervisors
- Pierreux, Christophe
- Abstract
- Development of a mature and functional pancreas is guided by an intrinsic program, but also by interactions with surrounding tissues. In the first part of my thesis, we found that endothelial cells produce abundant laminin-111, an extracellular matrix protein, in a regionalized manner. Laminin-111 repressed acinar differentiation, only allowing expression of the pro-acinar transcription factors Ptf1a and Rbpjl, and thus acinar differentiation, at a distance from blood vessels. In the second part, we studied the tight junction protein MarvelD3 in the pancreas, and investigated its role by gene inactivation. We found that despite a very early expression, MarvelD3 is not required for normal pancreas development and function. However, preliminary data in mouse models of pancreatic diseases suggest that MarvelD3 could impact on acinar-to-ductal-metaplasia upon caerulein-induced pancreatitis, and on precancerous PanIN lesions development upon oncogenic KRas expression.
- Affiliations
Citations
Heymans, C. (2020). Role of laminin-111 in pancreatic acinar differentiation and of MarvelD3 in pancreas development and disease. https://hdl.handle.net/2078.5/117478