Nanoparticles of Polyisohexylcyanoacrylate (pihca) As Carriers of Primaquine - Formulation, Physicochemical Characterization and Acute Toxicity
(1991) International Journal of Pharmaceutics — Vol. 68, n° 1-3, p. 111-119 (1991)
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- Abstract
- Nanoparticles of polyisohexylcyanoacrylate with bound primaquine were prepared by an emulsion polymerization method and an i.v. formulation was obtained after freeze-drying. Such formulation is intended for drug targeting in visceral leishmaniasis. Drug binding seemed largely dependent on pH and formulation conditions were optimized to obtain a polymeric colloidal suspension containing particles in the 200-250 nm size range and 80-90% drug binding (final content of 10 mg of drug per vial). Aspects such as polymer-drug interaction, in vitro drug release and physicochemical stability were studied. A significant reduction in acute toxicity was demonstrated by using the targeted formulation in NMRI mice.
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Citations
Gaspar, R., Préat, V., & Roland, M. (1991). Nanoparticles of Polyisohexylcyanoacrylate (pihca) As Carriers of Primaquine - Formulation, Physicochemical Characterization and Acute Toxicity. International Journal of Pharmaceutics, 68(1-3), 111-119. https://doi.org/10.1016/0378-5173(91)90133-9 (Original work published 1991)