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Abstract
Acanthamoeba infection is a rare, difficult-to-treat, and often fatal, opportunistic parasitic infection in immunocompromised hosts, such as patients infected with HIV. We describe an aggressive nasal and sinus infection by Acanthamoeba spp. in a person with AIDS. The resolution of this Acanthamoeba infection was secondary to a multidisciplinary treatment approach involving a combination of surgery as well as high-dose amphotericin B plus 5-fluorocytosine. In the era of the HIV/AIDS pandemic, the present report underscores the need for early identification and prompt aggressive treatment to ensure successful management of this rare but potentially fatal opportunistic infection.
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Nachega, J. B., Rombaux, P., Weynand, B., Thomas, G., & Zech, F. (2005). Successful treatment of Acanthamoeba rhinosinusitis in a patient with AIDS. AIDS Patient Care and S T Ds, 19(10), 621-625. https://doi.org/10.1089/apc.2005.19.621 (Original work published 2005)