Antibiotic resistance in Vietnam in relation with persistent forms of infection
(2020)
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- Authors
- Supervisors
- Van Bambeke, Françoise
- Abstract
- This thesis studies the activity of antibiotics on S. aureus collected in Vietnam from persistent or recurrent infections, in an attempt to elucidate the reasons for this persistence/recurrence for one specific antibiotic, moxifloxacin. We confirm a high rate of resistance in Vietnam (50% MRSA-83% MDR). Our work on MXF showed that the persister character, as established in-vitro, promotes the evolution of resistance (faster increase in MIC for persistant isolates). Moreover, it is predictive of a reduced efficacy against intracellular forms of infection (more abundant residual inoculum) and of the capacity to produce biofilms with an abundant, enriched in polysaccharides. The persister character of a clinical isolate could be an important determinant in its capacity to adopt persistent modes of life and to escape to antibiotic action, suggesting the interest of detecting this persiter character in routine in the hospital microbiology laboratories.
- Affiliations
Citations
Nguyen, K. T. (2020). Antibiotic resistance in Vietnam in relation with persistent forms of infection. https://hdl.handle.net/2078.5/117656