Effects of age, sex, and physical training on left ventricular function in normal population
(1988)
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- Abstract
- This work is divided into three parts. <BR> Part one dealt with the principles, techniques, applications and limitations of the radionuclide isotopic ventriculography in research and clinical practice as a method to study left ventricular function at rest and during exercise and thereafter the validation of this method by simultaneous right-heart catheterization in a group of healthy subjects before applying it for further studies dealing with the effects of age and sex on left ventricular function. We found that this method is reliable to study left ventricular volumetric response to exercise when a trend of a group is studied. <BR> Part two focused on the effects of age and sex on left ventricular function and volumes at rest and during upright exercise in healthy subjects. After a comprehensive review of literature cardiovascular physiology mainly during exercise, I presented our own results concerning the volumetric response and hemodynamic response of the cardiovascular system during upright maximal exercise in young and old normal volunteers and demonstrating the effects of age and sex on their adaptation to exercise. We concluded that age influences physical and hemodynamic response to exercise and showed how elderly compensate for the age related decrease in maximal heart rate y cardiac dilation and Frank Starling mechanism. <BR> In part three, I discussed the effects of physical training in left ventricular anatomical and functional parameters using echocardiography at rest in a group of young volunteers before and after six months of intensive regular physical training and correlating changes in maximal oxygen consumption (the best parameter to measure physical capacity) with changes in resting left ventricular end-diastolic volume and left ventricular mass. We observed significant physical and anatomical changes after physical training in physical performance represented by VO2 max and on left ventricular volume and mass calculated by echocardiographic method.
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Younis, L. T. (1988). Effects of age, sex, and physical training on left ventricular function in normal population. https://hdl.handle.net/2078.5/111993