Guillain-BarrÉ syndrome subtype diagnosis: A prospective multicentric European study.
(2018) Muscle & Nerve — Vol. 58, n° 1, p. 23-28 (2018)
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Van den Bergh, Peter 
- Abstract
- (en) INTRODUCTION: There is uncertainty as to whether the Guillain-Barré syndrome (GBS) subtypes, acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN), can be diagnosed electrophysiologically. METHODS: We prospectively included 58 GBS patients. Electrodiagnostic testing (EDX) was performed at means of 5 and 33 days after disease onset. Two traditional and one recent criteria sets were used to classify studies as demyelinating or axonal. Results were correlated with anti-ganglioside antibodies and reversible conduction failure (RCF). RESULTS: No classification shifts were observed, but more patients were classified as axonal with recent criteria. RCF and anti-ganglioside antibodies were present in both subtypes, more frequently in the axonal subtype. DISCUSSION: Serial EDX has no effect on GBS subtype proportions. The absence of exclusive correlation with RCF and anti-ganglioside antibodies may challenge the concept of demyelinating and axonal GBS subtypes based upon electrophysiological criteria. Frequent RCF indicates that nodal/paranodal alterations may represent the main pathophysiology. Muscle Nerve, 2018.
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Van den Bergh, P., Piéret, F., Woodard, J. L., Attarian, S., Grapperon, A.-M., Nicolas, G., Brisset, M., Cassereau, J., Rajabally, Y. A., Van Parys, V., Verougstraete, D., Jacquerye, P., Raymackers, J.-M., Redant, C., Michel, C., & Delmont, E. (2018). Guillain-BarrÉ syndrome subtype diagnosis: A prospective multicentric European study. Muscle & Nerve, 58(1), 23-28. https://doi.org/10.1002/mus.26056 (Original work published 2018)