Cutting edge : IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.
(2004) Journal of Immunology — Vol. 172, n° 4, p. 2006-2010 (2004)
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- The receptor for IL-26 (AK155), a cytokine of the IL-10 family, has not previously been defined. We demonstrate that the active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20R1 and IL-10R2. Signaling through the IL-26R results in activation of STAT1 and STAT3 which can be blocked by neutralizing Abs against IL-20R1 or IL-10R2. IL-10R2 is broadly expressed on a wide variety of tissues, whereas only a limited number of tissues express IL-20R1. Therefore, the ability to respond to IL-26 is restricted by the expression of IL-20R1. IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26.
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Sheikh, F., Baurin, V. V., Lewis-Antes, A., Shah, N. K., Smirnov, S. V., Anantha, S., Dickensheets, H., Dumoutier, L., Renauld, J.-C., Zdanov, A., Donnelly, R. P., & Kotenko, S. V. (2004). Cutting edge : IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Journal of Immunology, 172(4), 2006-2010. https://doi.org/10.4049/jimmunol.172.4.2006 (Original work published 2004)