GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer.

Watson, Richard L; Spalding, Aaron C; Zielske, Steven P; Morgan, Meredith; Kim, Alex C; Bommer, Guido; Eldar-Finkelman, Hagit; Giordano, Thomas; Fearon, Eric R; Hammer, Gary D; Lawrence, Theodore S; Ben-Josef, Edgar

GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer.

Watson, Richard L

;

Spalding, Aaron C

;

Zielske, Steven P

;

Morgan, Meredith

;

Ben-Josef, Edgar

;et.al.

(2010) NeoPlasia : an international journal of oncology research — Vol. 12, n° 5, p. 357-365 (2010)

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Authors

Watson, Richard LUniversity of Michigan
Author
Spalding, Aaron CUniversity of Michigan
Author
Zielske, Steven PUniversity of Michigan
Author
Morgan, MeredithUniversity of Michigan
Author
Bommer, GuidoUCLouvain
Author
Ben-Josef, EdgarUniversity of Michigan
Author

Abstract

These data support the hypothesis that GSK3beta modulates the cellular response to radiation in a beta-catenin-dependent mechanism. Further understanding of this pathway may enhance the development of clinical trials combining drugs inhibiting beta-catenin activation with radiation and chemotherapy in locally advanced pancreatic cancer.

Affiliations

UCLouvainSSS/DDUV - Institut de Duve
autreUniversity of Michigan

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Watson, R. L., Spalding, A. C., Zielske, S. P., Morgan, M., Kim, A. C., Bommer, G., Eldar-Finkelman, H., Giordano, T., Fearon, E. R., Hammer, G. D., Lawrence, T. S., & Ben-Josef, E. (2010). GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer. NeoPlasia : an international journal of oncology research, 12(5), 357-365. https://hdl.handle.net/2078.5/205310 (Original work published 2010)