Effets de l'oxyde d'azote sur la contraction du muscle strié squelettique
(1999) 24th Conference Society for biomechanics — Location: Lille
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- Authors
Maréchal, Georges 
- Abstract
- Nitrogen oxide (NO) is normally present in striated muscles where it is synthesized at the expense of arginine by NO synthase, an enzyme whose activity in the sarcoplasm is very high. The effects of NO on muscle fall into two groups. In the first group, the effects are direct, due to the nitrosation or nitrosylation of iron or sulfur of the target proteins. The general consequence of the direct effects is therefore to 'slow down' the contraction and its associated metabolism. In the second group, the effects of NO occur via a mediator, cyclic GMP. The general consequence of NO effects exerted indirectly by cyclic GMP is to improve the mechanical and metabolic power of the muscle, in a manner similar to the transformation of a slow muscle into a fast muscle, with the difference that NO control takes place in seconds instead of weeks. The indirect effects of NO seem to contribute to adapting the power of the muscle to the physiological demands of exercise, while the direct effects would occur under abnormal circumstances in excess of NO production,
Citations
Maréchal, G. (1999). Effets de l’oxyde d’azote sur la contraction du muscle strié squelettique. Archives of Physiology and Biochemistry : the journal of metabolic diseases, 107(sup), 11. https://hdl.handle.net/2078.5/214657 (Original work published 1999)