Is a patient's self-reported health-related quality of life a prognostic factor for survival in non-small-cell lung cancer patients? A multivariate analysis of prognostic factors of EORTC study 08975

Efficace, F;Bottomley, A;Smit, E.;Lianes, P;Van Meerbeeck, J;et.al.
(2006) Annals of Oncology — Vol. 17, n° 11, p. 1698-1704 (2006)

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Authors
  • Efficace, F
    Author
  • Bottomley, A
    Author
  • Smit, E.
    Author
  • Lianes, P
    Author
  • Legrand, CatherineUCLouvain
    Author
  • Van Meerbeeck, J
    Author
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Abstract
Abstract Background: The aim of this prognostic factor analysis was to investigate if a patient's self-reported health-related quality of life (HRQOL) provided independent prognostic information for survival in non-small cell lung cancer (NSCLC) patients. Patients and methods: Pretreatment HRQOL was measured in 391 advanced NSCLC patients using the EORTC QLQ-C30 and the EORTC Lung Cancer module (QLQ-LC13). The Cox proportional hazards regression model was used for both univariate and multivariate analyses of survival. In addition, a bootstrap validation technique was used to assess the stability of the outcomes. Results: The final multivariate Cox regression model retained four parameters as independent prognostic factors for survival: male gender with a hazard ratio (HR) = 1.32 (95% CI 1.03–1.69; P = 0.03); performance status (0 to 1 versus 2) with HR = 1.63 (95% CI 1.04–2.54; P = 0.032); patient's self-reported score of pain with HR= 1.11 (95% CI 1.07–1.16; P < 0.001) and dysphagia with HR = 1.12 (95% CI 1.04–1.21; P = 0.003). A 10-point shift worse in the scale measuring pain and dysphagia translated into an 11% and 12% increased in the likelihood of death respectively. A risk group categorization was also developed. Conclusion: The results suggest that patients' self-reported HRQOL provide independent prognostic information for survival. This finding supports the collection of such data in routine clinical practice.
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Efficace, F., Bottomley, A., Smit, E., Lianes, P., Legrand, C., Debruyne, C., Schramel, F., Smit, H., Gaafar, R., Biesma, B., Manegold, C., Coens, C., Giaccone, G., & Van Meerbeeck, J. (2006). Is a patient’s self-reported health-related quality of life a prognostic factor for survival in non-small-cell lung cancer patients? A multivariate analysis of prognostic factors of EORTC study 08975. Annals of Oncology, 17(11), 1698-1704. https://doi.org/10.1093/annonc/mdl183 (Original work published 2006)