There is a demand for serum markers for the routine assessment of the progression of liver cancer. We previously found that serum N-linked sugar chains are altered in hepatocellular carcinoma (HCC). Here, we studied glycomic alterations during development of HCC in a rat model.
Fang, M., Dewaele, S., Zhao, Y.-P., Starkel, P., Vanhooren, V., Chen, Y.-M., Ji, X., Luo, M., Sun, B.-M., Horsmans, Y., Dell, A., Haslam, S. M., Grassi, P., Libert, C., Gao, C.-F., & Chen, C. C. (2010). Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat. Molecular Cancer, 9, 215. https://doi.org/10.1186/1476-4598-9-215 (Original work published 2010)