Efficacy and Safety of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis With and Without Fever at Baseline: Results From an Open-Label, Active-Treatment Extension Study.

Brunner, Hermine I;Quartier, Pierre;Alexeeva, Ekaterina;Constantin, Tamàs;Paediatric Rheumatology International Trials Organisation, the Pediatric Rheumatology Collaborative Study Group;et.al.
(2020) Arthritis & Rheumatology — Vol. 72, n° 12, p. 2147-2158 (2020)

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Authors
  • Brunner, Hermine Iorcid-logo
    Author
  • Quartier, Pierre
    Author
  • Alexeeva, Ekaterina
    Author
  • Constantin, Tamàs
    Author
  • Lauwerys, BernardUCLouvain
    Author
  • Paediatric Rheumatology International Trials Organisation, the Pediatric Rheumatology Collaborative Study Group
    Collaborator
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Abstract
OBJECTIVE: To evaluate the long-term efficacy and safety of canakinumab and explore prediction of response in patients with systemic juvenile idiopathic arthritis (JIA) with or without fever at treatment initiation. METHODS: At enrollment, patients with active systemic JIA (ages 2 to <20 years) started open-label canakinumab (4 mg/kg every 4 weeks subcutaneously). Efficacy measures included the adapted American College of Rheumatology (ACR) Pediatric 50/70/90 criteria, the Juvenile Arthritis Disease Activity Score (JADAS), and clinically inactive disease and clinical remission on medication, evaluated by either the JADAS or ACR criteria. RESULTS: Of the 123 patients (70 with fever and 52 without fever [fever status was not reported for 1 patient]), 84 (68.3%) completed the study (median duration 1.8 years). Comparable efficacy (adapted ACR Pediatric 50/70/90/100) was observed by day 15 in both subgroups (60.0%/48.6%/37.1%/24.3% in those with fever and 67.3%/48.1%/34.6%/19.2% in those without fever), and further increased thereafter. By month 6, clinical remission according to the JADAS or the ACR criteria was achieved in 17 (24.3%) and 26 (37.1%), respectively, of patients with fever and 9 (17.3%) and 12 (23.1%), respectively, of patients without fever. Median time to onset of clinical remission according to the JADAS or ACR criteria was 57 and 30 days, respectively, in those with fever, and 58 and 142 days, respectively, in those without fever. An adapted ACR Pediatric 50 response by day 15 was the strongest predictor of achieving clinical remission according to the JADAS (odds ratio [OR] 13 [95% confidence interval (95% CI) 4, 42]; P < 0.0001) or glucocorticoid discontinuation (OR 19 [95% CI 3, 114]; P = 0.002). Of the 71 of 123 patients (57.7%) who received glucocorticoids at study entry, 27 (38.0%) discontinued glucocorticoids and 21 (29.6%) reached a dose of <0.2 mg/kg/day, with no difference between those with and those without fever; 13 patients (10.6%) tolerated a sustained canakinumab dose reduction to 2 mg/kg every 4 weeks. No new safety findings were observed. CONCLUSION: Canakinumab provided rapid and sustained improvement of active systemic JIA irrespective of the presence of fever at treatment initiation.
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Brunner, H. I., Quartier, P., Alexeeva, E., Constantin, T., Koné-Paut, I., Marzan, K., Schneider, R., Wulffraat, N. M., Chasnyk, V., Tirosh, I., Kallinich, T., Kuemmerle-Deschner, J., Wouters, C., Lauwerys, B., Nikishina, I., Trachana, M., Vougiouka, O., Martini, A., Lovell, D. J., et al. (2020). Efficacy and Safety of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis With and Without Fever at Baseline: Results From an Open-Label, Active-Treatment Extension Study. Arthritis & Rheumatology, 72(12), 2147-2158. https://doi.org/10.1002/art.41436 (Original work published 2020)