Cancer metabolism in space and time: beyond the Warburg effect.
(2017) Biochimica et Biophysica Acta : international journal of biochemistry and biophysics — Vol. 1858, n° 8, p. 556-572 (2017)
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- Authors
Danhier, Pierre 
- Abstract
- Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing energy, reducing equivalents and building blocks while several metabolites exert a signaling function promoting tumor growth and progression. A cancer tissue cannot be simply reduced to a bulk of proliferating cells. Tumors are indeed complex and dynamic structures where single cells can heterogeneously perform various biological activities with different metabolic requirements. Because tumors are composed of different types of cells with metabolic activities affected by different spatial and temporal contexts, it is important to address metabolism taking into account cellular and biological heterogeneity. In this review, we describe this heterogeneity also in metabolic fluxes, thus showing the relative contribution of different metabolic activities to tumor progression according to the cellular context. This article is part of a Special Issue entitled Respiratory complex I, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.
- Affiliations
Citations
Danhier, P., Banski, P., Payen, V., Grasso, D., Ippolito, L., Sonveaux, P., & Porporato, P. (2017). Cancer metabolism in space and time: beyond the Warburg effect. Biochimica et Biophysica Acta : international journal of biochemistry and biophysics, 1858(8), 556-572. https://doi.org/10.1016/j.bbabio.2017.02.001 (Original work published 2017)