Inhibition by amlodipine of activity evoked in isolated human coronary arteries by endothelin, prostaglandin F2 alpha and depolarization

Godfraind, Theophile;Mennig, Damien;Bravo, Guadalupe;Chalant, Charles;Jaumin, Pierre
(1989) The American Journal of Cardiology — Vol. 64, n° 17, p. 58I-64I (1989)

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Authors
  • Godfraind, TheophileUCLouvain
    Author
  • Mennig, Damien
    Author
  • Bravo, Guadalupe
    Author
  • Chalant, CharlesUCLouvain
    Author
  • Jaumin, Pierre
    Author
Abstract
Amlodipine, a dihydropyridine calcium antagonist has been examined on the rhythmic activity of isolated human coronary arteries. Amlodipine inhibited both the spontaneous rhythmic activity and the rhythmic activity evoked by prostaglandin F2 alpha and endothelin in isolated human coronary arteries. It also inhibited the contraction evoked by potassium depolarization. The action of amlodipine was characterized by slow onset and voltage dependency.
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Godfraind, T., Mennig, D., Bravo, G., Chalant, C., & Jaumin, P. (1989). Inhibition by amlodipine of activity evoked in isolated human coronary arteries by endothelin, prostaglandin F2 alpha and depolarization. The American Journal of Cardiology, 64(17), 58I-64I. https://doi.org/10.1016/0002-9149(89)90961-2 (Original work published 1989)