Crohn's disease stable remission after human immunodeficiency virus infection
(1998) Digestive Diseases and Sciences — Vol. 43, n° 2, p. 412-419 (1998)
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- Abstract
- We retrospectively assessed the clinical course in four patients with long-standing Crohn's disease who became infected with human immunodeficiency virus (HIV), The duration of active Crohn's disease was 21, 10, 4, and 4 years in our four patients, They experienced a stable remission of Crohn's disease symptoms after HIV infection, In three patients Crohn's disease was in stable remission for 5, 8, and 8 years after HIV infection and all three died from acquired immunodeficiency syndrome-related disease. One patient was still alive without recurrence of Crohn's disease symptoms 7 years following HIV detection, Our observations of a spontaneous improvement in the clinical course of Crohn's disease after HIV infection, suggests that the integrity of the immune response, especially that of CD4 T cells, plays a major role in the tissue injury mechanism in Crohn's disease.
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Pospai, D., Vandercam, B., Rene, E., Fiasse, R., Farahat, K., Beaugery, L., Lammens, P., Reimund, C., Duclos, B., Le Quintrec, Y., & Mignon, M. (1998). Crohn’s disease stable remission after human immunodeficiency virus infection. Digestive Diseases and Sciences, 43(2), 412-419. https://doi.org/10.1023/A:1018883112012 (Original work published 1998)