Diethyltin(iv) and Di-normal-butyltin(iv) 3-amino-4-methylbenzoates - Synthesis, Spectroscopic Characterization and Invitro Antitumor-activity
(1992) Societes Chimiques Belges. Bulletin — Vol. 101, n° 3, p. 243-248 (1992)
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- Diethyl- and di-n-butyltin(IV) oxides react with 3-amino-4-methylbenzoic acid in a 1:2 (a) and 1:1 (b) molar ratio to yield dialkyltin compounds of the types R2Sn[O2C-C6H3-3-NH2-4-CH3]2 (a) and {[R2Sn(O2C-C6H3-3-NH2-4-CH3)]2O}2 (b). The compounds obtained were characterized by H-1, C-13, Sn-119 NMR and by Mossbauer spectroscopy. Compound 1a was tested in vitro against two human tumor cell lines, MCF-7, a mammary tumor, and WiDr, a colon carcinoma.
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Gielen, M., Elkhloufi, A., Biesemans, M., Mahieu, B., & Willem, R. (1992). Diethyltin(iv) and Di-normal-butyltin(iv) 3-amino-4-methylbenzoates - Synthesis, Spectroscopic Characterization and Invitro Antitumor-activity. Societes Chimiques Belges. Bulletin, 101(3), 243-248. https://doi.org/10.1002/bscb.19921010313 (Original work published 1992)