Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus.
(2004) Immunity — Vol. 21, n° 6, p. 769-780 (2004)
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- Abstract
- Susceptibility to autoimmunity in B6.Sle1b mice is associated with extensive polymorphisms between two divergent haplotypes of the SLAM/CD2 family of genes. The B6.Sle1b-derived SLAM/CD2 family haplotype is found in many other laboratory mouse strains but only causes autoimmunity in the context of the C57Bl/6 (B6) genome. Phenotypic analyses have revealed variations in the structure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sle1b mice. T lymphocytes from B6.Sle1b mice have modified signaling responses to stimulation at 4-6 weeks of age. While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes.
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Citations
Wandstrat, A. E., Nguyen, C., Limaye, N., Chan, A. Y., Subramanian, S., Tian, X.-H., Yim, Y.-S., Pertsemlidis, A., Garner, H. R., Morel, L., & Wakeland, E. K. (2004). Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity, 21(6), 769-780. https://doi.org/10.1016/j.immuni.2004.10.009 (Original work published 2004)