Upregulation of IL-17, but not of IL-9, in circulating cells of CIS and relapsing MS patients. Impact of corticosteroid therapy on the cytokine network.
(2012) Journal of Neuroimmunology — Vol. 243, n° 1-2, p. 73-80 (2012)
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- The concomitant production of IL-17A and IL-9, both Th17 cytokines, has not been compared in MS patients. We show that IL-17A but not IL-9 expression by CD3+ cells was increased during a MS relapse. Co-expression of IL-17A and IL-9 was marginal. In addition to Th1 and Th2 cytokines, IL-17A, IL-6 and IL-23p19 were down-regulated by ivMP, but Foxp3 was not, while an increase in IL-10, TGF-β1 and IL-27p28 mRNA was observed. This change in the Th17, Treg and IL-10 balance could be an additional mechanism by which corticosteroids shorten the duration of a MS relapse and promote recovery.
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Muls, N., Jnaoui, K., Dang, H. A., Wouters, A., Van Snick, J., Sindic, C., & Van Pesch, V. (2012). Upregulation of IL-17, but not of IL-9, in circulating cells of CIS and relapsing MS patients. Impact of corticosteroid therapy on the cytokine network. Journal of Neuroimmunology, 243(1-2), 73-80. https://doi.org/10.1016/j.jneuroim.2011.12.010 (Original work published 2012)