Comparison of unenhanced and gadoxetate disodium-enhanced spin-echo magnetic resonance imaging for the detection of experimental hepatocellular carcinoma in the rat.

Goudemant, Jean-François;Van Beers, Bernard;Demeure, R.;Grandin, Cécile;Pringot, Jacques;et.al.
(1998) Investigative Radiology : a journal of clinical and laboratory research — Vol. 33, n° 2, p. 80-84 (1998)

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  • Goudemant, Jean-FrançoisUCLouvain
    Author
  • Van Beers, BernardUCLouvain
    Author
  • Demeure, R.
    Author
  • Grandin, CécileUCLouvain
    Author
  • Delos, MoniqueUCLouvain
    Author
  • Pringot, JacquesUCLouvain
    Author
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Abstract
RATIONALE AND OBJECTIVES: The authors compare the potential value of unenhanced and gadoxetate disodium-enhanced spin-echo images for the detection of hepatocellular carcinoma in a rat model. METHODS: Eleven rats with chemically induced hepatocellular carcinoma underwent unenhanced T2-weighted fast spin-echo imaging followed by T1-weighted spin-echo imaging before and at 5 minutes, 30 minutes, 3 hours, 1 day, and 3 days after intravenous administration of 60 micromol/kg gadoxetate disodium at 4.7 tesla. Tumor and liver enhancement, and tumor-to-liver contrast-to-noise (C/N) ratio were calculated. RESULTS: After gadoxetate disodium administration, the tumors showed less enhancement than the liver. Tumor-to-liver C/N ratio increased from 5.5 +/- 0.8% on unenhanced T1-weighted images to 12.9 +/- 2.4% on gadoxetate-enhanced T1-weighted images (P = 0.02). However, the C/N ratio on unenhanced T2-weighted images (23.5 +/- 3.6%) remained higher than that on gadoxetate-enhanced T1-weighted images, a difference that is statistically significant (P < 0.01). CONCLUSIONS: In the experimental setting of our study, the higher tumor-to-liver C/N ratio on unenhanced T2-weighted spin-echo images suggests that unenhanced T2-weighted spin-echo images are superior to gadoxetate disodium-enhanced T1-weighted spin-echo images for the detection of hepatocellular carcinoma.
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Goudemant, J.-F., Van Beers, B., Demeure, R., Grandin, C., Delos, M., & Pringot, J. (1998). Comparison of unenhanced and gadoxetate disodium-enhanced spin-echo magnetic resonance imaging for the detection of experimental hepatocellular carcinoma in the rat. Investigative Radiology : a journal of clinical and laboratory research, 33(2), 80-84. https://doi.org/10.1097/00004424-199802000-00004 (Original work published 1998)