Historical overview of analytical methods for the measurement of transthyretin.
(2002) Clinical Chemistry and Laboratory Medicine : Associated with FESCC and IFCC — Vol. 40, n° 12, p. 1271-1273 (2002)
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- The history of prealbumin dates back to the early forties and may be divided into three parts, based on a chronological and functional approach. The first part--the discovery and the identification of prealbumin--was essentially based on classical protein chemistry methods. The second--the demonstration of prealbumin as a thyroid hormone-binding protein (thyroxine-binding prealbumin)--has greatly benefited from isotopic techniques. The third one--establishing prealbumin as a nutritional marker--was a result of field studies on nutrition. The discovery of the role of prealbumin in retinol binding led to a change in its name, prealbumin becoming transthyretin. Finally, structural studies and mutation analysis of transthyretin in patients with amyloid neuropathy have opened a new area of research.
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De Nayer, P. (2002). Historical overview of analytical methods for the measurement of transthyretin. Clinical Chemistry and Laboratory Medicine : Associated with FESCC and IFCC, 40(12), 1271-1273. https://doi.org/10.1515/CCLM.2002.220 (Original work published 2002)