Identification of J-chain in polymeric immunoglobulins from a variety of species by cross-reaction with rabbit antisera to human J-chain

Kobayashi, Kunihiko;Vaerman, Jean-Pierre;Bazin, Hervé;LeBacq-Verheyden, Anne-Marie;Heremans, Joseph F.
(1973) Journal of Immunology — Vol. 111, n° 5, p. 1590-1594 (1973)

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Authors
  • Kobayashi, Kunihiko
    Author
  • Vaerman, Jean-PierreUCLouvain
    Author
  • Bazin, HervéUCLouvain
    Author
  • LeBacq-Verheyden, Anne-Marie
    Author
  • Heremans, Joseph F.
    Author
Abstract
Two rabbit antisera, rendered specific for human J chains, were shown to cross-precipitate extensively with J chains of completely reduced and alkylated polymeric immunoglobulins (IgA, IgM, and/or SIgA) from the dog, cat, cow, goat, sheep, pig, horse, hedgehog, guinea pig, rat, mouse, and chicken. The data emphasize the great evolutionary stability of the J polypeptide chain.
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Kobayashi, K., Vaerman, J.-P., Bazin, H., LeBacq-Verheyden, A.-M., & Heremans, J. F. (1973). Identification of J-chain in polymeric immunoglobulins from a variety of species by cross-reaction with rabbit antisera to human J-chain. Journal of Immunology, 111(5), 1590-1594. https://hdl.handle.net/2078.5/108297 (Original work published 1973)