Diabetic macro- and microvascular disease in type 2 diabetes

Hermans, Michel
(2007) Diabetes and Vascular Disease Research — Vol. 4, n° SUPPL. 2 (2007)

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Abstract
Before a patient develops overt type 2 diabetes mellitus, there is typically a prolonged period of pathophysiological change. In the common form of type 2 diabetes mellitus, there are years of insulin resistance, initially compensated by increased beta cell function, then impaired glucose tolerance develops, and finally type 2 diabetes. We know from studies such as the United Kingdom Prospective Diabetes Study (UKPDS) and the Belfast study that loss of beta cell function and insulin resistance are usually relentless.<sup>1,2</sup> Thus, therapy to reduce blood glucose has to be gradually increased with time for patients with diabetes. What is less well known is that every person has a different slope for beta cell function loss which intersects with insulin resistance.
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Hermans, M. (2007). Diabetic macro- and microvascular disease in type 2 diabetes. Diabetes and Vascular Disease Research, 4(SUPPL. 2). https://doi.org/10.3132/dvdr.2007.019 (Original work published 2007)