Nutritional regulation of the growth hormone and insulin-like growth factor-binding proteins.
(1996) Hormone Research — Vol. 45, n° 3-5, p. 252-257 (1996)
Files
No attached file found for this publication.
Details
- Authors
Thissen, Jean-Paul 
- Abstract
- Both growth hormone (GH) and insulin-like growth factors (IGFs) associate with specific binding proteins. Besides control by hormones, these binding proteins are nutritionally regulated. The GH-binding protein (GHBP) is the extracellular portion of the GH receptor. Its concentrations in circulation are decreased in severe malnutrition, reflecting a decrease in tissue GH receptor abundance. IGFs are bound to 6 different binding proteins (IGFBPs). IGFBP-3 is relatively stable and is only depressed after prolonged periods of severe malnutrition. In contrast, IGFBP-1 is regulated acutely by nutrient intake, showing major elevations after overnight fasting and rapid postprandial decreases. IGFBP-2 is highly dependent on dietary protein intake. Nutritional factors may regulate the tissue availability and the biological actions of IGFs by their actions on IGFBPs.
- Affiliations
Citations
Ketelslegers, J.-M., Maiter, D., Maes, M., Underwood, L. E., & Thissen, J.-P. (1996). Nutritional regulation of the growth hormone and insulin-like growth factor-binding proteins. Hormone Research, 45(3-5), 252-257. https://doi.org/10.1159/000184797 (Original work published 1996)