Laminar Distribution of Alpha-1-adrenoceptors and Beta-1-adrenoceptors in Ferret Visual-cortex

Goffinet, André;Rockland, Kathleen S.
(1985) Brain Research — Vol. 333, n° 1, p. 11-17 (1985)

Files

pdfdocument.pdf
  • Restricted Access
  • Adobe PDF
  • 2.59 MB
Request a copy

Details

Authors
  • Goffinet, AndréUCLouvain
    Author
  • Rockland, Kathleen S.Department of Neurology, Harvard Medical School, Boston, MA U.S.A.
    Author
Abstract
The distribution ofα1-andβ1-adrenoceptors has been examined in the ferret visual cortex (area 17), with an autoradiographic procedure using iodine-125 labeled hydroxy-iodophenyl-ethylaminomethyl-tetralone (HEAT) and iodocyanopindolol (ICYP), respectively. The density of ligand binding with ICYP, known to have selective affinity for β-receptors, was heavy over layers I-III, very low over layer IV, and medium over V and VI. In contrast, binding sites for HEAT, a new ligand selective for α-receptors, were diffusely distributed, although preferentially concentrated in layer IV and the upper layers. The distinct laminar distribution of these two receptor types may imply two cortical channels for norepinephrine influence;α1-receptors may be preferentially associated with enhancement of excitatory inputs to layer IV;β1-receptors, in contrast, with enhancement of inhibitory responses outside layer IV.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Goffinet, A., & Rockland, K. S. (1985). Laminar Distribution of Alpha-1-adrenoceptors and Beta-1-adrenoceptors in Ferret Visual-cortex. Brain Research, 333(1), 11-17. https://doi.org/10.1016/0006-8993(85)90118-0 (Original work published 1985)