Detection of tumour hypoxia: comparison between EF5 adducts and [18F]EF3 uptake on an individual mouse tumour basis.

Mahy, Pierre;De Bast, Marc;Gillart, Jacques;Labar, Daniel;Grégoire, Vincent
(2006) European Journal of Nuclear Medicine and Molecular Imaging — Vol. 33, n° 5, p. 553-556 (2006)

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Authors
  • Mahy, PierreUCLouvain
    Author
  • De Bast, MarcUCLouvain
    Author
  • Gillart, JacquesUCLouvain
    Author
  • Labar, DanielUCLouvain
    Author
  • Grégoire, VincentUCLouvain
    Author
Abstract
In the framework of the preclinical validation of the hypoxic tracer [(18)F]EF3, a comparison was performed between uptake of [(18)F]EF3 and EF5 adducts detected by immunofluorescence in MCa-4, FSA, FSAII, Sa-NH and NFSA tumour-bearing mice. Mice were allowed to breath carbogen (5% CO(2), 95% O(2)), 21% oxygen or 10% oxygen. A significant correlation (r (2)=0.57; p<0.01) was found between the [(18)F]EF3 tumour-to-muscle ratio and the fluorescence intensity of EF5.
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Mahy, P., De Bast, M., Gillart, J., Labar, D., & Grégoire, V. (2006). Detection of tumour hypoxia: comparison between EF5 adducts and [18F]EF3 uptake on an individual mouse tumour basis. European Journal of Nuclear Medicine and Molecular Imaging, 33(5), 553-556. https://doi.org/10.1007/s00259-005-0049-3 (Original work published 2006)