Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism.

Pieretti, Simone;Haanstra, Jurgen R;Mazet, Muriel;Perozzo, Remo;Cavalli, Andrea;et.al.
(2013) PLoS Neglected Tropical Diseases — Vol. 7, n° 1, p. e2012 (2013)

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Authors
  • Pieretti, Simone
    Author
  • Haanstra, Jurgen R
    Author
  • Mazet, Muriel
    Author
  • Perozzo, Remo
    Author
  • Michels, PaulusUCLouvain
    Author
  • Cavalli, Andrea
    Author
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Abstract
Overall, B6 showed a multitarget mechanism of action, which provides a molecular explanation of its promising anti-trypanosomatid activity. Furthermore, the forward chemical genetics approach here applied may be viable in the molecular characterization of novel multitarget ligands.
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Pieretti, S., Haanstra, J. R., Mazet, M., Perozzo, R., Bergamini, C., Prati, F., Fato, R., Lenaz, G., Capranico, G., Brun, R., Bakker, B. M., Michels, P., Scapozza, L., Bolognesi, M. L., & Cavalli, A. (2013). Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism. PLoS Neglected Tropical Diseases, 7(1), e2012. https://doi.org/10.1371/journal.pntd.0002012 (Original work published 2013)