Pharmacological Aspects of Anandamide and 2-Arachidonoyglycerol as Bioactive Lipids
(2017) Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment — ISBN: [978-012800827-0;978-012800756-3], 616-629, published
Files
AlhouayekandMuccioli.pdf
Restricted Access - Adobe PDF
- 910.77 KB
Details
- Authors
- Abstract
- The endocannabinoids N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) are bioactive lipids implicated in numerous pathophysiological processes, such as inflammation, analgesia, mood disorders, food intake, and obesity. Classically, they exert their effects by activating two G protein-coupled receptors, the cannabinoid receptors 1 and 2. The actions of AEA and 2-AG are terminated by their hydrolysis by specific lipases into arachidonic acid and ethanolamine or glycerol, respectively. However, due to their arachidonoyl moiety, AEA and 2-AG can also be metabolized by enzymes of the eicosanoids pathway, such as cyclooxygenase-2 (COX-2), lipoxygenase, and cytochrome P450 enzymes. This oxidative metabolism is not merely a means to end the endocannabinoid signaling, but leads to the production of bioactive lipids in their own right that can exert a variety of actions. The COX-2-derived prostaglandin-ethanolamides and prostaglandin-glycerol esters are examples of such bioactive lipids, and add to the complexity of endocannabinoid signaling. © 2017 Elsevier Inc. All rights reserved.
- Affiliations
Citations
Al Houayek, M., & Muccioli, G. (2017). Pharmacological Aspects of Anandamide and 2-Arachidonoyglycerol as Bioactive Lipids. In Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment (pp. 616-629). Elsevier. https://doi.org/10.1016/B978-0-12-800756-3.00074-0