Hypothyroidism Associated With Myeloid Neoplasia About 2 Cases

Boonen, AL.;Lefebvre, Chantal;Lambert, Michel;Ferrant, Augustin;Coche, Edgard;et.al.
(1992) Acta Clinica Belgica (Multilingual Edition) — Vol. 47, n° 6, p. 397-400 (1992)

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Authors
  • Boonen, AL.
    Author
  • Lefebvre, Chantal
    Author
  • Lambert, MichelUCLouvain
    Author
  • Ferrant, Augustin
    Author
  • Coche, EdgardUCLouvain
    Author
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Abstract
We report 2 cases of hypothyroidism in whom the associated haematological disturbances (macrocytic anaemia in both cases, mild leukopenia and thrombopenia in one patient) failed to be corrected by thyroid hormone replacement therapy. Further investigations led to the diagnosis of acute myeloid leukaemia (AML) in the first patient and myelodysplastic syndrome (MDS) in the other. The reasons of the delayed diagnosis and the possible mechanisms explaining this rare combination are discussed. The hypothesis of a purely coincidental association seems most likely.
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Boonen, AL., Lefebvre, C., Lambert, M., Ferrant, A., Michaux, JL., & Coche, E. (1992). Hypothyroidism Associated With Myeloid Neoplasia About 2 Cases. Acta Clinica Belgica (Multilingual Edition), 47(6), 397-400. https://hdl.handle.net/2078.5/89827 (Original work published 1992)