Real-life experience of micropulse transscleral cyclophotocoagulation (MP-TSCPC) in advanced and uncontrolled cases of several glaucoma types: a multicentric retrospective study.

Laruelle, Gregory;Pourjavan, Sayeh;Janssens, Xavier;Marinescu-George, Cristina;Boustani, Gabriel
(2021) International Ophthalmology — Vol. 41, n° 10, p. 3341-3348 (2021)

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Authors
  • Laruelle, Gregoryorcid-logoUCLouvain
    Author
  • Pourjavan, SayehUCLouvain
    Author
  • Janssens, Xavier
    Author
  • Marinescu-George, Cristina
    Author
  • Boustani, Gabriel
    Author
Abstract
PURPOSE: In this retrospective case series multicentric study, we assessed the efficiency and safety of micropulse transscleral cyclophotocoagulation (MP-TSCPC) among several types of advanced uncontrolled glaucoma cases. This study was intended to be a real-life study. METHODS: We treated 55 eyes with the Iridex Cyclo G6 device with the MP3 handpiece (IRIDEX Laser Systems) using a standardized protocol. Patients were followed up for a period of one year with an intention-to-treat protocol. Observation points are day 1, week 1, month 1, month 3, month 6, month 9 and year 1 after treatment. The primary outcome is a significant decrease in intra-ocular pressure (IOP) with a threshold of 20% reduction. The secondary outcomes are a reduction in the number of topical molecules needed to control glaucoma progression and the discontinuation of oral acetazolamide. RESULTS: We observed a significant IOP reduction at every observation point with a mean preoperative IOP of 24.19 mmHg (SEM: 0.96) and mean IOP at final follow-up was 19.50 mmHg (SEM: 1.20). At least 50% of patients reached the significant threshold of 20% IOP reduction at every observation point except for month 6 follow-up. No significant reduction was achieved in the number of topical medications necessary to control glaucoma progression. Mean number of topical medications used at final follow-up is 3.00 (SEM: 0.134). Mean number of topical molecules preoperatively was 3.08 (SEM: 0.138). The discontinuation of oral acetazolamide was obtained with a statistically significant difference (p = 0.003). CONCLUSION: Thanks to the design of this study, we add some proofs about the efficiency and the safety of MP-TSCPC for the treatment of uncontrolled advanced glaucoma cases in a real-life practice.
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Laruelle, G., Pourjavan, S., Janssens, X., Marinescu-George, C., & Boustani, G. (2021). Real-life experience of micropulse transscleral cyclophotocoagulation (MP-TSCPC) in advanced and uncontrolled cases of several glaucoma types: a multicentric retrospective study. International Ophthalmology, 41(10), 3341-3348. https://doi.org/10.1007/s10792-021-01896-w (Original work published 2021)