Risk Factors for Reintervention in Children with Subvalvular Aortic Stenosis: A 20-Year Single-Center Study
(2025) Journal of Cardiovascular Development and Disease — Vol. 12, n° 10, p. 413 (2025)
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- Authors
Hubrechts, Jelena 
Detaille, Thierry
- Abstract
- Subvalvular aortic stenosis (SAS) is a frequent cause of left ventricular outflow tract (LVOT) obstruction in children. Surgical resection is the standard treatment, yet recurrence requir ing reintervention remains a significant concern. We aim to identify risk factors associated with surgical reintervention. This retrospective study included 76 patients under 18 years whounderwent surgical resection for SAS between 2000 and 2020. Preoperative, intraoper ative, and postoperative data were analyzed. The mean age at initial surgery was 5.8 years. In addition to subaortic membrane resection, myomectomy was performed in 73.7% of patients. Reintervention was required in 13.1% of cases, with reintervention-free survival at 5 and 10 years of 93.4% and 89.5%, respectively. Significant predictors of reintervention included younger age and shorter stature at surgery. Myomectomy reduced postoperative gradients but was not protective against recurrence and was associated with a higher rate of conductive disorders requiring pacemakers. While surgical resection of SAS is associated with excellent survivalrecurrence remains a concern, especially in younger patients and those with tunnel-like lesions. Individualized surgical planning is essential to balance recurrence risk with potential complications.
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Citations
Hubrechts, J., Zanfardino, A., Barrea, C., Detaille, T., & Poncelet, A. (2025). Risk Factors for Reintervention in Children with Subvalvular Aortic Stenosis: A 20-Year Single-Center Study. Journal of Cardiovascular Development and Disease, 12(10), 413. https://doi.org/10.3390/jcdd12100413 (Original work published 2025)