Thrombotic microangiopathy induced by long-term interferon-β therapy for multiple sclerosis
(2011) Clinical Nephrology — Vol. 76, n° 5, p. 396-400 (2011)
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- Abstract
- We report the case of a 53-year-old woman treated for 8 years with Betaferon® (interferon-β-1b), who developed mild renal failure with hypertension, proteinuria and glomerular hematuria. Kidney biopsy was consistent with thrombotic microangiopathy (TMA). Considering the strong evidence of interferon-α causing TMA and the numerous immunomodulatory activities shared by INF-α and -β, we incriminated Betaferon as the etiological agent of TMA in our patient. To our knowledge, it is the first time such an association has been published.
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Broughton, A., Cosyns, J.-P., & Jadoul, M. (2011). Thrombotic microangiopathy induced by long-term interferon-β therapy for multiple sclerosis. Clinical Nephrology, 76(5), 396-400. https://doi.org/10.5414/CN106523 (Original work published 2011)