Stable Chromosome-aberrations 25 Years After Severe Accidental Radiation Exposure

Maes, Andrée;Hilali, A.;Leonard, ED.;Leonard, A.;Verschaeve, L.
(1993) Radiation and Environmental Biophysics — Vol. 32, n° 4, p. 319-324 (1993)

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Authors
  • Maes, AndréeUCLouvain
    Author
  • Hilali, A.
    Author
  • Leonard, ED.
    Author
  • Leonard, A.UCLouvain
    Author
  • Verschaeve, L.
    Author
Abstract
A thorough cytogenetic analysis using G-banding was performed on 100 peripheral blood lymphocytes from an individual who had been accidentally exposed to radiation more than 25 years previously. More than 60% of the analysed cells were found to possess one or more stable chromosome aberrations (e.g. reciprocal translocations). Chromosomes 1 and 11 were more involved in these aberrations than would be expected from the relative chromosome lengths. No identical stable aberrations were found, suggesting that, 25 years after near-lethal exposure, haemopoietic stem cells display substantial diversity.
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Citations

Maes, A., Hilali, A., Leonard, ED., Leonard, A., & Verschaeve, L. (1993). Stable Chromosome-aberrations 25 Years After Severe Accidental Radiation Exposure. Radiation and Environmental Biophysics, 32(4), 319-324. https://doi.org/10.1007/BF01225919 (Original work published 1993)