Gender dependent accumulation of dioxins in smokers.
(2005) Occupational and Environmental Medicine : an international peer-reviewed journal in all aspects of occupational & environmental medicine — Vol. 62, n° 1, p. 61-62 (2005)
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- Abstract
- AIMS: To evaluate the contribution of tobacco smoking to dioxin accumulation. METHODS: Dioxin (17 PCDD/F) concentrations in fasting blood from 251 subjects (161 never smokers, 54 past smokers, and 36 current smokers) were quantified. RESULTS: Whereas serum dioxin concentrations of male smokers were on average 40% higher than those of non-smokers, in women, smoking was associated with significantly lower serum dioxin levels. A synergistic potentiation of dioxin metabolism by tobacco smoke in women is postulated to explain these paradoxical findings. CONCLUSIONS: Current smoking is associated with gender dependent effects on dioxin body burden and is a potential source of confounding in human studies using blood dioxins as indicators of exposure.
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Fierens, S., Eppe, G., De Pauw, E., & Bernard, A. (2005). Gender dependent accumulation of dioxins in smokers. Occupational and Environmental Medicine : an international peer-reviewed journal in all aspects of occupational & environmental medicine, 62(1), 61-62. https://doi.org/10.1136/oem.2004.013730 (Original work published 2005)