Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses
(2007)
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- Authors
- Abstract
- The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) genes in a hypoxic cell. More particularly, the methods disclosed herein relate to inhibition of HIF-1 activation in a cell, increasing sensitivity of a tumor cell to radiation and/or chemotherapy, delaying tumor growth, inhibiting tumor blood vessel growth, inhibiting inflammatory responses in a cell through the use of compositions that prevent the nitrosylation of HIF 1, and methods for screening for new inhibitors of HIF-1 activiation. Additionally, the compositions disclosed herein relate to compositions that can be employed in, and are identified by, the disclosed methods.
- Affiliations
Duke University Medical School Department of Radiation Oncology
Citations
Li, C.-Y., li, F., Sonveaux, P., & Dewhirst, M. W. (2007). Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses (Patent No. 11/731,719). https://hdl.handle.net/2078.5/255430