Exploration of untargeted metabolomic extraction methods for in vitro malaria samples by 1HNMR analysis
(2022) Séminaire CIRM — Location: (Belgium) Liège (2022)
Files
2022_Mamede_CIRM_Poster.pdf
Open Access - Adobe PDF
- 585.56 KB
Details
- Authors
Govaerts, Bernadette 
- Abstract
- Metabolomics is a reliable omics tool to study the metabolome, the assortment of metabolites that provide energy, signaling or building blocks essential for biological systems survival. • Malaria is a deadly disease, especially severe when caused by Plasmodium falciparum, that still affects over 200 million people yearly.1 • The metabolome closely reflects the state of the biological system, and if applied to the P. falciparum, it can be used to characterize antimalarial mechanisms of action or study resistance. • The parasite’s intracellular nature, in red blood cells in suspension, introduces significant hurdles to metabolomics extraction methods.
- Affiliations
Citations
Mamede, L., Schoumacher, M., Cirillo, A., Fall, F., Bugli, C., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Govaerts, B., & Frédérich, M. (2022). Exploration of untargeted metabolomic extraction methods for in vitro malaria samples by 1HNMR analysis. Séminaire CIRM, (Belgium) Liège. https://hdl.handle.net/2078.5/24080