Post-infectious olfactory loss: a cohort study and update
(2009) Summer School on Human Olfaction — Location: Dresden (19.July.2009)
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- Abstract
- In this prospective study, we examined a cohort of 122 patients suffering from post-infectious olfactory loss. Post-infectious olfactory loss is defined as an olfactory dysfunction in the course of an upper respiratory tract infection. The aim of this study was to point out the clinical characteristic of the cohort of patients. Every patient received an ORL investigation, including nasal endoscopy, an interview, psychophysical tests (ortho- and retro- olfaction), electrophysiological recordings and a MRI. The results of our investigations confirmed previous findings : typically, post-infectious olfactory patients are middle aged women (sex ratio: 2.4; mean age: 53.9) , with 47.5% and 18% of them complaining respectively of parosmia and phantosmia, with more hyposmic than anosmic patients (64.7% vs 35.3%) and with repetitive episodes for 18 of them. We also showed a significant correlation between the olfactory bulb volume and TDI score (p>0.001), and between the orthonasal and retronasal testing (p<0.001). Olfactory event-related potentials could be interpreted in 115 of the patients. Among these recordings, 35 (30.4%) showed olfactory event-related potentials, while 109 (94.7%) presented trigeminal event-related potentials. In conclusion, this study confirmed the previous findings about the clinical characteristics of the post infectious olfactory loss, pointed out correlation between olfactory bulb volume and psychophysical testing, and finally showed that almost all patients presented trigeminal event-related potentials while only a third had olfactory event-related potentials. As no medical therapy has yet proven its efficacy for this disease, complete clinical evaluation may help in counselling the patients for the recovery prognosis that may happen for one third of the patients.
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Citations
Rombaux, P., Martinage, S., Huart, C., & Collet, S. (2009). Post-infectious olfactory loss: a cohort study and update. Frontiers in Human Neuroscience, 10.3389/conf.neuro.09.2009.12.012(10.3389/conf.neuro.09.2009.12.012), 10. https://doi.org/10.3389/conf.neuro.09.2009.12.012 (Original work published 2009)